Details

<p>List of Contributors, vii</p> <p>Introduction, xiii</p> <p>1 Central Nervous System Manifestations of Chromosomal Change, 1</p> <p><i>Joseph R. Siebert</i></p> <p>2 Neural Tube Defects, 13</p> <p><i>Andrew J. Copp and Brian N. Harding</i></p> <p>3 Midline Patterning Defects, 29</p> <p><i>Edwin S. Monuki and Jeffrey A. Golden</i></p> <p>4 Microcephaly, 41</p> <p><i>Sandrine Passemard, Annie Laquerriere, ` Nathalie Journiac, and Pierre Gressens</i></p> <p>5 Hemimegalencephaly and Dysplastic Megalencephaly, 55</p> <p><i>Ghayda Mirzaa, Achira Roy, William B. Dobyns, Kathleen Millen, and Robert F. Hevner</i></p> <p>6 Lissencephaly, Type I, 63</p> <p><i>Jeffrey A. Golden</i></p> <p>7 Lissencephaly, Type II (Cobblestone Lissencephaly), 75</p> <p><i>Jeffrey A. Golden</i></p> <p>8 Polymicrogyria, 85</p> <p><i>Jeffrey A. Golden</i></p> <p>9 Cerebral Heterotopia, 91</p> <p><i>Edwin S. Monuki and Keith L. Ligon</i></p> <p>10 Hippocampal Sclerosis, Granule Cell Dispersion, and Cortical Dysplasia, 101</p> <p><i>Maria Thom</i></p> <p>11 Tuberous Sclerosis Complex, 117</p> <p><i>Shino D. Magaki and Harry V. Vinters</i></p> <p>12 Chiari Malformations, 133</p> <p><i>Homa Adle-Biassette and Jeffrey A. Golden</i></p> <p>13 Dandy–Walker Malformation, Mega Cisterna Magna, and Blake’s Pouch Cyst, 141</p> <p><i>Robert F. Hevner, Kathleen Millen, and William B. Dobyns</i></p> <p>14 Joubert Syndrome, 151</p> <p><i>Robert F. Hevner, William B. Dobyns, and Enza Maria Valente</i></p> <p>15 Cerebellar Heterotopia and Dysplasia, 159</p> <p><i>Marie Rivera-Zengotita and Anthony T. Yachnis</i></p> <p>16 Brainstem Malformations, 167</p> <p><i>Brian N. Harding</i></p> <p>17 Spinal Cord Lesions, 179</p> <p><i>Annie Laquerriere and Florent Marguet </i></p> <p>18 Hydrocephalus, 187</p> <p><i>Homa Adle-Biassette</i></p> <p>19 Antenatal Disruptive Lesions, 199</p> <p><i>Brian N. Harding</i></p> <p>20 Hemorrhagic Lesions, 203</p> <p><i>Marc R. Del Bigio</i></p> <p>21 White Matter Lesions in the Perinatal Period, 213</p> <p><i>Robin L. Haynes and Rebecca D. Folkerth</i></p> <p>22 Gray Matter Lesions, 229</p> <p><i>Marc R. Del Bigio</i></p> <p>23 Pediatric Head Injury, 241</p> <p><i>Colin Smith, Thomas S. Jacques, and R. Ross Reichard</i></p> <p>24 Pediatric Vascular Malformations, 251</p> <p><i>Shino D. Magaki, Randy Tashjian, and Harry V. Vinters</i></p> <p>25 Sudden Infant Death Syndrome, 269</p> <p><i>Hannah C. Kinney, Marco M. Hefti, Richard D. Goldstein, and Robin L. Haynes</i></p> <p>26 Kernicterus, 281</p> <p><i>Mariarita Santi and Lucy B. Rorke</i></p> <p>27 Lesions Induced by Toxins, 285</p> <p><i>Mariarita Santi, Lucy B. Rorke, and Catherine Keohane</i></p> <p>28 Disorders of Carbohydrate Metabolism, 293</p> <p><i>Josefine Radke, Carsten G. Bonnemann, ¨ Werner Stenzel, and Hans-H. Goebel</i></p> <p>29 Sphingolipidoses and Related Disorders, 313</p> <p><i>Annie Laquerriere, Soumeya Bekri, Kinoko Suzuki, and Brian N. Harding</i></p> <p>30 The Neuronal Ceroid Lipofuscinoses, 369</p> <p><i>Josefine Radke, Krystina E. Wisniewski, Werner Stenzel, and Hans-H. Goebel</i></p> <p>31 Peroxisomal Disorders, 381</p> <p><i>Phyllis L. Faust</i></p> <p>32 Mitochondrial Disorders, 393</p> <p><i>Anders Oldfors and Brian N. Harding</i></p> <p>33 Disorders of Amino Acid Metabolism and Canavan Disease, 403</p> <p><i>Dimitri P. Agamanolis</i></p> <p>34 Pelizaeus–Merzbacher Disease, 417</p> <p><i>Brian N. Harding</i></p> <p>35 Cockayne Syndrome, 427</p> <p><i>Karen M. Weidenheim and P. J. Brooks</i></p> <p>36 Vanishing White Matter Disease, 437</p> <p><i>Marianna Bugiani, James M. Powers, and Marjo S. van der Knaap</i></p> <p>37 Alexander Disease, 447</p> <p><i>James E. Goldman and Mel B. Feany</i></p> <p>38 Neuroaxonal Dystrophy/Neurodegeneration with Brain Iron Accumulation, 455</p> <p><i>Abi Li, Sarah Wiethoff, Charles Arber, Henry Houlden, Tamas Revesz, and Janice L. Holton</i></p> <p>39 Spinal Muscular Atrophy, 469</p> <p><i>Brian N. Harding</i></p> <p>40 Autism Spectrum Disorders, 477</p> <p><i>Matthew P. Anderson</i></p> <p>41 Intrauterine Infections, 497</p> <p><i>Catherine Keohane and Homa Adle-Biassette</i></p> <p>42 Perinatal and Postnatal Infections, 511</p> <p><i>Catherine Keohane</i></p> <p>43 Rasmussen Encephalitis, 531</p> <p><i>Harry V. Vinters, Shino D. Magaki, and Geoffrey C. Owens</i></p> <p>Index, 537</p>

<p><b>Homa Adle-Biassette</b> Inserm U676, Université Paris Diderot (P7), Hôpital Robert Debré, Paris, France.</p> <p><b>Brian Harding</b> Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.</p> <p><b>Jeffrey Golden</b> Ramzi S. Cotran Professor of Pathology, Harvard Medical School, and Chair of Pathology Brigham and Women's Hospital, Boston, MA, USA.</p>

<p><b>A DEFINITIVE, CLINICALLY ORIENTED GUIDE TO THE PATHOLOGY OF GENETICS OF DEVELOPMENTAL NEUROPATHOLOGY</b> <p>Developmental neuropathology relates to the wide range of disorders affecting the developing brain or pre- and post-natal life, with emphasis on the genetic and molecular mechanisms involved. This book provides a practical guide to diagnosing and understanding these disorders affecting this vulnerable population and potentially stimulates further advances in this exciting area. It also addresses the controversies in inflicted head injury in infants. <p>The fourth major title published in association with the International Society of Neuropathology (ISN), <i>Developmental Neuropathology</i> offers in-depth chapter coverage of brain development; chromosomal changes; malformations; secondary malformations and destructive pathologies; developmental vascular disorders; acquired metabolic and exogenous toxins; metabolic disorders; Rett syndrome and autism; and infectious diseases. <ul> <li>Clinical, disease-oriented approach to the pathology and genetics developmental neuropathology</li> <li>Fuses classical and contemporary investigative approaches</li> <li>Includes genetic and molecular biological pathogeneses</li> <li>Fully illustrated</li> <li>Approved and endorsed by International Society of Neuropathology</li> </ul> <p><i>Developmental Neuropathology</i> is the perfect book for practicing neuropathologists, pediatric pathologists, general pathologists, neurologists, and geneticists in deciphering the pathology and pathogenesis of these complex disorders affecting the nervous system of the embryo, fetus, and child.

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