Details
Bacterial and Eukaryotic Porins
Structure, Function, Mechanism1. Aufl.
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142,99 € |
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| Verlag: | Wiley-VCH (D) |
| Format: | |
| Veröffentl.: | 06.03.2006 |
| ISBN/EAN: | 9783527604227 |
| Sprache: | englisch |
| Anzahl Seiten: | 382 |
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Beschreibungen
This first book dedicated to the topic relates the known physiological functions of porins to their molecular structure and mechanism, as documented by various in vitro and in vivo methods, including the generation of null mutants in mice.<br> For the first time, it brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function.<br> With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this essential protein family.
Preface. <p>List of Contributors.</p> <p>1. Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR (D. Walthers, <i>et al</i>.).</p> <p>2. The Structures of General Porins (G. Schulz).</p> <p>3. Role of Bacterial Porins in Antibiotic Susceptibility of Gram-negative Bacteria (J. Pagés).</p> <p>4. Porins of the Outer Membrane of <i>Pseudomonas aeruginosa</i> (R. Hancock & S. Tamber).</p> <p>5. Regulation of Bacterial Porin Function (A. Baslé & A. Delcour).</p> <p>6. Reconstitution of General Diffusion Pores from Bacterial Outer Membranes (C. Danelon & M. Winterhalter).</p> <p>7. OmpA/OprF: Slow Porins or Channels Produced by Alternative Folding of Outer Membrane Proteins (E. Sugawara & H. Nikaido).</p> <p>8. Drug Efflux and Protein Export through Channel-tunnels (C. Andersen).</p> <p>9. Structure-Function Relationships in Sugar-Specific Porins (T. Schirmer).</p> <p>10. Functional Reconstitution of Specific Porins (R. Benz & F. Orlik).</p> <p>11. Energy-coupled Outer Membrane Iron Transporters (V. Braun & M. Braun).</p> <p>12. Structural and Functional Aspects of the Vitamin B<sub>12</sub> Receptor BtuB (R. Kadner, <i>et al</i>.).</p> <p>13. Structure and Function of Mitochondrial (Eukaryotic) Porins (R. Benz).</p> <p>14. Mitochondrial Porins in Mammals: Insights Into Functional Roles from Mutant Mice and Cells (K. Anflous & W. Craigen).</p> <p>15. Gene Family Expression and Multitopological Localization of Eukaryotic Porin/Voltage Dependent Anion-selective Channel (VDAC): Intracellular Trafficking and Alternative Splicing (V. De Pinto & A. Messina).</p> <p>16. Function of the Outer Mitochondrial Membrane Pore (Voltage-dependent Anion Channel) in Intracellular Signalling (M. Vyssokikh & D. Brdiczka).</p> <p>Index.<br /> </p>
"…a scholarly research monograph on the biophysical aspects of porins…recommended for molecular and structural biologists working with porin proteins and academic libraries…" (<i>E-STREAMS</i>, May 2005) <p>“This excellent book should be present in all laboratories…the information is extremely up-to-date and is supported by high-quality and highly original graphics.” (<i>International Microbiology</i>, Vol.7, 2004)</p>
<b>Roland Benz</b> (born 1943) studied Mathematics, Chemistry and Physics at the University of Würzburg (Germany) before joining the group of Peter Läuger at Konstanz University, where he obtained his PhD in Biology and his habilitation in Biophysics. Recipient of a Heisenberg Fellowship of the German Research Society (DFG), he was a Visiting Professor at the State University of New York in 1980 and again in 1982, and at the University of British Columbia in Vancouver in 1984. Since 1986 he is full Professor of Biotechnology at the University of Würzburg. His research is centered on the molecular basis of membrane transport in microorganisms and higher organisms, with a special interest into pore-forming peptides and proteins.
For the first time, current knowledge on this important of proteins is now available in a single resource. This first book on porins in prokaryotes and eukaryotes relates the known physiological functions of porins to their molecular structure and mechanism. It brings together biophysical evidence with studies performed in a cellular context, presenting a unified picture of the fundamental importance of porins for cellular function.<br /> <br /> <b>From the contents:</b> <ul> <li>Structure of Prokaryotic Porins</li> <li>Functional Reconstitution of Porins</li> <li>Regulation of Bacterial Porin Function</li> <li>Role of Porins in Antibiotic Susceptibility</li> <li>Drug Efflux and Protein Export through Porins</li> <li>Structure and Function of Mitochondrial Porins</li> <li>VDAC Function in Intracellular Signalling and Apoptosis</li> </ul> <p>With 16 contributions by an interdisciplinary team of leading porin researchers, this reference is essential reading for every molecular or structural biologist with an interest in this important protein family.</p>
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