Details
GPCRs as Therapeutic Targets
2 Volume Set
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303,99 € |
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| Verlag: | Wiley |
| Format: | EPUB |
| Veröffentl.: | 19.09.2022 |
| ISBN/EAN: | 9781119564720 |
| Sprache: | englisch |
| Anzahl Seiten: | 1056 |
DRM-geschütztes eBook, Sie benötigen z.B. Adobe Digital Editions und eine Adobe ID zum Lesen.
Beschreibungen
<p><b>A thorough discussion of the structure, pharmacology, function, and role of G protein-coupled receptors</b> <p>In <i>GPCRs as Therapeutic Agents</i>, distinguished researcher Dr. Annette Gilchrist delivers an authoritative and in-depth compendium of a vibrant and active area of academic and industrial drug discovery. The book serves as an important reference for new and experienced researchers studying G protein-coupled receptors and discusses the molecular pharmacology of this important target class. It also includes up-to-date material on GPCR structures and structure-based drug design. <p>The book explores the role of GPCRs in the treatment of disease and novel approaches to their study. In addition to providing information on the structure, pharmacology, and function of GPCRs, it discusses their role in disease states, and advances new methods for measuring GPCR activity in an accessible and engaging way. The book includes: <ul> <li>A thorough introduction to the molecular pharmacology of G protein-coupled receptors, including up-to-date material on GPCR structures and structure-based drug design</li> <li>In-depth discussions of the evolving pharmacology for GPCRs, intracellular trafficking, and subcellular GPCR signaling</li> <li>Comprehensive explorations of allosteric modulation, receptor dimerization, deorphanization, and ubiquitination</li> <li>Fulsome treatments of the role played by GPCRs in the treatments of cancer, substance use disorders, cerebrovascular diseases, and metabolic diseases</li></ul><p>Perfect for researchers in biochemistry, cell biology, and pharmacology, <i>GPCRs as Therapeutic Agents</i> will also earn a place in the libraries of professionals working in medicinal chemistry, structural biology, and clinical pharmacology.
<p>Chapter 1 - An overview of G protein coupled receptors and their signaling partners</p> <p>Chapter 2 - Recent advances in orphan GPCRs research and therapeutic potential</p> <p>Chapter 3 - The Evolution of Our Understanding of GPCRs</p> <p>Chapter 4 - Approaching GPCR dimers and higher order oligomers using biophysical, biochemical and proteomic methods</p> <p>Chapter 5 - Arrestin and G protein interactions with GPCRs: a structural perspective</p> <p>Chapter 6 - GPCRs at endosomes: sorting, signaling, and recycling</p> <p>Chapter 7 - Post-translational Control of GPCR Signaling</p> <p>Chapter 8 - GPCR Signaling from Intracellular Membranes</p> <p>Chapter 9 - Ten years of GPCR structures</p> <p>Chapter 10 - Activation of class B GPCR by peptide ligands: general structural aspects</p> <p>Chapter 11 - Dynamical basis of GPCR-G-protein coupling selectivity and promiscuity</p> <p>Chapter 12 - Virtual Screening and Bioactivity Modeling for G Protein‐Coupled Receptors</p> <p>Chapter 13 - Importance of structure and dynamics in the rational drug design of</p> <p>G protein-coupled receptor (GPCR) modulators</p> <p>Chapter 14 - Signaling, Physiology and Targeting of GPCR-Regulated Phospholipase C Enzymes</p> <p>Chapter 15 - G Protein-coupled Receptors in Metabolic Disease</p> <p>Chapter 16 - Endothelin Receptors in cerebrovascular diseases</p> <p>Chapter 17 - The calcium-sensing receptor (CaSR) in disease</p> <p>Chapter 18 - G protein-coupled receptors and their mutations in cancer – a focus on adenosine receptors</p> <p>Chapter 19 - Dopamine Receptors: Neurotherapeutic Targets for Substance Use Disorders</p> <p>Chapter 20 - PTHR1 in bone</p> <p>Chapter 21 - Activators of G-protein Signaling in the normal and diseased kidney</p> <p>Chapter 22 - Screening and characterization of GPCR-ligand interactions with mass spectrometry-based technologies</p> <p>Chapter 23 - Bioluminescence resonance energy transfer (BRET) technologies to study GPCRs</p> <p>Chapter 24 - The Application of 19F NMR to Studies of Protein Function and Drug Screening</p> <p>Chapter 25 - Chapter X: Optical Approaches for Dissecting GPCR Signaling</p> <p>Chapter 26 - GPCR Signaling in Nanodomains: Lessons from Single-Molecule Microscopy</p>
<p><b>Annette Gilchrist, PhD, </b>is an Associate Professor at Midwestern University in the Department of Pharmaceutical Sciences.
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