EDITED BY
Laurence J. N. Cooper, MD, PhD
Elizabeth A. Mittendorf, MD, PhD
Judy Moyes, MB, BChir, FRCP(C), FRCPCH
Sabitha Prabhakaran, PhD
This edition first published 2018 © 2018 by John Wiley & Sons, Inc.
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Library of Congress Cataloging‐in‐Publication Data
Names: Cooper, Laurence J. N., editor. | Mittendorf, Elizabeth A., editor. | Moyes, Judy, 1953– editor. | Prabhakaran, Sabitha, editor.
Title: Immunotherapy in translational cancer research / [edited by] Laurence J.N. Cooper, Elizabeth A. Mittendorf, Judy Moyes, Sabitha Prabhakaran.
Description: Hoboken, NJ : Wiley, 2018. | Series: Translational oncology | Includes bibliographical references and index. |
Identifiers: LCCN 2017056123 (print) | LCCN 2017057426 (ebook) | ISBN 9781118684504 (pdf) | ISBN 9781118684528 (epub) | ISBN 9781118123225 (hardback)
Subjects: | MESH: Neoplasms–therapy | Translational Medical Research | Immunomodulation | Clinical Trials as Topic
Classification: LCC RC271.I45 (ebook) | LCC RC271.I45 (print) | NLM QZ 266 | DDC 616.99/406–dc23
LC record available at https://lccn.loc.gov/2017056123
Cover design: Wiley
Cover images: (Left image) © royaltystockphoto.com/Shutterstock; (Upper right image) © CI Photos/Shutterstock; (Lower right image) © molekuul_be/Shutterstock
Laurence J. N. Cooper
Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Elizabeth A. Mittendorf
Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Judy Moyes
Pediatrics Research, MD Anderson Cancer Center, Houston, TX, USA
Sabitha Prabhakaran
Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Gheath Alatrash
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Miles C. Andrews
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Paul M. Armistead
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
Lohith S. Bachegowda
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas, MD Anderson Cancer Center, Houston TX, USA
Alexandra P. Cadena
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Richard E. Champlin
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas, MD Anderson Cancer Center, Houston TX, USA
Alexandria P. Cogdill
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Saranya Chumsri
Department of Hematology and Oncology, Mayo Clinic, Jacksonville, FL, USA
Taylor R. Cushman
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Sandra Demaria
Radiation Oncology and Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA
Adi Diab
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Mary L. Disis
Tumor Vaccine Group, Center for Translational Medicine in Women’s Health, University of Washington, Seattle, WA, USA
Andrew D. Fesnak
Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Jennifer A. Foltz
Department of Hematology, Oncology, and Bone Marrow Transplantation, Nationwide Children’s Hospital, Columbus, OH, USA
Vidya Gopalakrishnan
Departments of Pediatrics and Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
William R. Gwin
Tumor Vaccine Group, Center for Translational Medicine in Women’s Health, University of Washington, Seattle, WA, USA
Garth S. HerbertDepartment of Surgery, San Antonio Military Medical Center, San Antonio, TX, USA
Dae won Kim
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA
Keith L. Knutson
Department of Immunology, Mayo Clinic, Jacksonville, FL, USA
Dean A. Lee
Department of Hematology, Oncology, and Bone Marrow Transplantation, Nationwide Children’s Hospital, Columbus, OH, USA
Bruce L. Levine
Department of Pathology and Laboratory Medicine and Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
Crystal Mackall
Division of Hematology/Oncology, Department of Pediatrics, Stanford University, Stanford, CA, USA
Nicola J. Mason
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
Jeffrey S. Miller
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Elizabeth A. Mittendorf
Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston,TX, USA
Jeffrey J. Molldrem
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Timothy Murray
Ludwig Cancer Research, Department of Oncology, University of Lausanne, Épalinges, Switzerland
M. Kazim Panjwani
School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
George E. PeoplesCancer Vaccine Development Program, San Antonio, TX, USA
Sabitha Prabhakaran
Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Peter A. Prieto
Department of Surgery, Oncology, University of Rochester Medical Center, School of Medicine and Dentistry, Rochester, NY, USA
Tracy A. Proverbs‐Singh
John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA
Jonathan E. Schoenhals
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston,TX, USA
Liora Schultz
Division of Hematology/Oncology, Department of Pediatrics, Stanford University, Stanford, CA, USA
Jonathan S. Serody
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA
Alexandra Snyder
Departments of Medicine at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA
Daniel E. Speiser
Ludwig Cancer Research, Department of Oncology, University of Lausanne, Épalinges, Switzerland
Jyothishmathi Swaminathan
Departments of Pediatrics and Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Eric Tran
Earle A. Chiles Research Institute, Providence Cancer Center, Portland, OR, USA
Timothy J. VreelandDepartment of Surgery, Womack Army Medical Center, Fort Bragg, NC, USA
Jennifer A. Wargo
Departments of Surgical Oncology and Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
James W. Welsh
Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA
Jedd Wolchok
Swim Across America–Ludwig Collaborative Research Laboratory, Immunology Program, Ludwig Center for Cancer Immunotherapy Department of Medicine at Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, NY, USA
Cassian Yee
Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
We live and work in the age of immunotherapy. The modality is now firmly affixed to the triad of chemotherapy, radiation therapy, and surgery. This book captures the translation of immunology into therapies. The migration of bench research to bedside experimentation has been largely driven by academia and amplified by industry; however, in the current age, there is equipoise between the not‐for‐profit and for‐profit enterprises regarding advancements in the human applications of immunotherapies.
The breadth of treatments reflects the complexity of the immune system itself. The coordinated response of the multiple components of an endogenous immune response has generated a portfolio of immunotherapy options that are reflected in the names of the chapters. Not all chapters, though, are created equally. Some immunotherapies are just beginning their human experimentation and some are seasoned and perhaps even seen as out of vogue. Nevertheless, as a whole, these components of immune‐based therapies provide patients with therapeutic optimism and some with therapeutic impact.
This book is a sum of its chapters and thus individual immunotherapies. What is not yet evident is how combinations of immune‐based therapies can be harnessed. This is undoubtedly needed in order to secure long‐term and complete treatment for the majority of malignancies, especially arising as solid tumors. The coordinated response of the endogenous immune system will be mirrored by the corradiated application of immunotherapies. However, that will be the topic of a future book. What is present and is remarkable, is that monotherapies based on harnessing the immune response have resulted in Lazarus‐type moments, are used to prevent cancer, and have provided responses in tumors that were previously considered untreatable.
Immunotherapy as presently wielded is a relatively blunt tool. Yet the immune system is built on precision. Academics and industry investigators are only beginning to understand how to sharpen the therapeutic edge of an applied immune response. The proving ground is the human experience as preclinical models by and large do not yield sufficient information regarding efficacy and toxicity. Thus, immunotherapy practitioners and patients alike are risk takers. Together, they will advance the clinical application of the immune system so that its complexity can be harnessed as an instrument to treat cancer on an individualized basis.
This is a good time to be studying immunotherapy, and we hope this book rewards your interest.